Abstract: The concept that rheumatoid arthritis (RA) is an autoimmune disease is supported by variety of autoantibodies in patient's serum. The most important of these are rheumatoid factors (RFs), antibodies that react with the patient's own Ig. It has been suggested that IgM-RF plays a role in disease pathogenesis. The main source of IgM-RF are B cells that express the pan T-cell marker, CDS: We conducted this study to test the ...
A SURVEY OF ANTIBODIES FOR THE EXTRACTABLE NUCLEAR ANTIGENS AND THEIR ROLE IN THE CLINICAL DIAGNOSIS AND PROGNOSIS OF SLE.
Abstract: Fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-DNA; anti-Sm (Smith's antigen); and, other extractable nuclear antigens. The tests employed were microhemagglutination, counter immunoelecterphoresis, and radio immunoassay (RIA). The comparison between the two techniques for detectiong anti-DNA titers showed a significant correlation between them. There was also a significant positive correlation between the presence of anti-DNA and lupus nephritis ...